They are several key areas of biological susceptibility that make it more likely that a person will develop a chronic illness and/or vaccine injury. People of African descent have genes that are optimized to a different environment than their Caucasian counterparts (on which most vaccines are tested). Recent research highlights this fact by demonstrating that persons of African descent mount a much more vigorous immune activation in response to RNA viruses. Also, they are more likely to have gene variations that, while protecting from Malaria, may compromise blood cells and the delivery of oxygen under highly inflammatory conditions, such as vaccination and COVID infection.